Structural mechanisms underlying the function of epithelial sodium channel/acid-sensing ion channel
نویسندگان
چکیده
منابع مشابه
Sensing tension: epithelial sodium channel/acid-sensing ion channel proteins in cardiovascular homeostasis.
The epithelial sodium (Na ) channel (ENaC) plays a critical role in blood pressure regulation by controlling renal salt and water reabsorption. Channel overactivity can lead to severe hypertension and underactivity to salt wasting and hypotension.1 In addition to their role in salt/water homeostasis, recent studies suggest that ENaC proteins, and their relatives, the acid-sensing ion channel (A...
متن کاملEpithelial Sodium Channel/Acid-Sensing Ion Channel Proteins in Cardiovascular Homeostasis
The epithelial sodium (Na ) channel (ENaC) plays a critical role in blood pressure regulation by controlling renal salt and water reabsorption. Channel overactivity can lead to severe hypertension and underactivity to salt wasting and hypotension.1 In addition to their role in salt/water homeostasis, recent studies suggest that ENaC proteins, and their relatives, the acid-sensing ion channel (A...
متن کاملStructural domains underlying the activation of acid-sensing ion channel 2a.
The acid-sensing ion channels (ASICs) are a family of ion channels expressed throughout the mammalian nervous system. The principal activator of ASICs is extracellular protons, and ASICs have been demonstrated to play a significant role in many physiologic and pathophysiologic processes, including synaptic transmission, nociception, and fear. However, not all ASICs are proton-sensitive: ASIC2a ...
متن کاملGain-of-function variant of the human epithelial sodium channel.
Epithelial Na(+) channel (ENaC) mutations are associated with several human disorders, underscoring the importance of these channels in human health. Recent human genome sequencing projects have revealed a large number of ENaC gene variations, several of which have been found in individuals with salt-sensitive hypertension, cystic fibrosis, and other disorders. However, the functional consequen...
متن کاملNedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel.
We previously reported the existence of multiple isoforms of human Nedd4-2 (Am J Physiol Renal Physiol 285: F916-F929, 2003). When overexpressed in M-1 collecting duct epithelia, full-length Nedd4-2 (Nedd4-2), Nedd4-2 lacking the NH(2)-terminal C2 domain (Nedd4-2DeltaC2), and Nedd4-2 lacking WW domains 2 and 3 (Nedd4-2DeltaWW2,3) variably reduce benzamil-sensitive Na(+) transport. We investigat...
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ژورنال
عنوان ژورنال: Current Opinion in Nephrology & Hypertension
سال: 2011
ISSN: 1062-4821
DOI: 10.1097/mnh.0b013e328348bcac